We are seeking driven, creative, and entrepreneurial individuals to help shape our company. At Alpha-9, you’ll find a culture of collaboration, transparency, and innovation. We are passionate about developing new medicines to help people living with cancer, and we are looking to add to our growing team.

Our Core Values

We are:
Innovative
Driven
Agile
Tenacious

We are:
Supportive
Respectful
Inclusive
Knowledgeable

We are:
Open
Transparent
Thought Partners
Accountable

Open Positions

Scientist, Chemistry, Peptides

About Us

Alpha-9 Oncology is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking a Scientist to join our Chemistry group.  The ideal candidate will have hands-on experience in synthetic organic chemistry, including in the synthesis, isolation and purification of either small molecules, peptides or peptidomimetics. This person will be responsible for synthesizing peptides/peptidomimetic building blocks and precursors for radiopharmaceutical product candidates. Expertise in solid-phase peptide synthesis and the optimization of peptide ligands required.

We are an early-stage company, so you will have the opportunity to participate cross-functionally and contribute to the build-out and set-up of new laboratory facilities.  The ideal candidate will have multi-tasking ability and a desire to strive in a fast-paced environment.

Some specific duties and tasks include, but are not limited to, the following:

  • Design and synthesis of peptides/peptidomimetics or small molecule-based building blocks and drug substances for radiopharmaceutical development
  • Working closely cross-functionally to achieve project goals
  • Supervision and mentoring of junior scientists
  • Compound characterization employing LC-MS/MS, GC-MS, HPLC and NMR
  • Lead project discussions and present results in team meetings
  • Key participant in the writing of patent applications
  • Maintenance of clear and accurate lab records, adherence to all safety and compliance requirements

Qualifications

  • PhD in Chemistry or related area with 5+ years of relevant industrial drug discovery experience
  • Solid understanding and practical experience in peptide drug discovery
  • Solid experience in modern synthetic and analytical techniques
  • Excellent observational, organizational, data management, and documentation skills

What’s in it for you

  • Full extended health benefits
  • Competitive salary, annual bonus, and equity
  • 20 vacation days
  • 14 holidays
  • 5 sick days
  • Group Registered Retirement Savings Plan with 5% employer match
  • Commuter reimbursement
  • Long term disability
  • Life insurance
  • Impactful and rewarding work

Schedule

  • Full Time Permanent

Location: Vancouver

Timing: ASAP

Lead Radiochemist – CMC

About Us:

Alpha-9 Oncology is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking a Lead Radiochemist to join our growing organization. The ideal candidate will have experience developing radiolabeling and analytical methods for targeted, peptide/small molecule-based radiopharmaceuticals. This person will be responsible for developing and delivering novel radiolabeled diagnostic and therapeutic compounds for both pre-clinical and clinical applications. This position requires a high degree of collaboration, multi-tasking ability, and desire to strive in a fast-paced environment. You will have the opportunity to contribute to the build-out and set-up of new laboratory facilities, interface with external partners, and mentor more junior staff.

Some specific duties and tasks include, but are not limited to, the following:

  • Develop radiolabelling and manufacturing methods for compounds with imaging and therapeutic applications.
  • Work in multidisciplinary teams to define development project goals and timelines.
  • Design and conduct radiochemistry experiments leading to robust radiolabelling processes and clinical formulations that meet target product profiles.
  • Critically evaluate data from internal and third-party experiments, draw appropriate conclusions and develop follow-up plans of actions.
  • Develop quality control procedures, analytical methods and specifications for radiopharmaceuticals/API.
  • Perform technology transfer of radiolabeling and analytical methods to third party CRO and CDMO partners.
  • Support pre-clinical development by radiolabeling compounds for in vitro and in vivo evaluation.
  • Demonstrated ability to troubleshoot, identify unusual results and design experiments that establish root cause and/or enhance knowledge of the product being developed.
  • Author, revise and review technical documents including SOPs, development reports, test method, experimental and qualification protocols, batch records, specifications and regulatory documentation.
  • Design transfer of manual process(es) to automated chemistry process(es) on automated synthesis modules.
  • Suggest and implement continuous improvements with respect to safe handling of radioactive substances in the laboratory environment.
  • Adhere and follow radiation safety regulations as set in the policies and conduct area radiation surveys, contamination control, radioactive waste management.

Qualifications:

  • PhD/MSc in Radiochemistry, Chemistry, Analytical Chemistry, Nuclear Engineering or equivalent knowledge or experience
  • 5+ years’ experience with academic and/or commercial radiopharmaceutical development and production
  • Hands on experience in radiolabeling with radioisotopes used for imaging and therapeutic applications; experience with alpha emitters is a plus.
  • Ability to plan and execute complex scientific projects.
  • Ability to handle more than one project at a time, multitasking, effective communicator and collaborative with different teams.
  • Functional knowledge of radiopharmaceutical process/formulation chemistry, standard concepts of radiochemistry, best practices, regulatory requirements for development of radiopharmaceuticals in various jurisdictions

What’s in it for you:

  • Full extended health and dental benefits
  • Competitive Salary, Bonus, and Equity
  • Commuter Reimbursement
  • Group Registered Retirement Savings Plan with employer matching.
  • 20 vacation days
  • 14 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

Location: Vancouver, BC

Scientist, Translational Biology

About Us:

Alpha-9 Oncology is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking a Scientist to join our Translational Biology group within our growing organization. The ideal candidate should have knowledge and hands-on experience in microSPECT/PET/CT imaging in rodent models, in vivo experiments in general for drug development, preferably for applications using radiopharmaceuticals. The candidate will work collaboratively and cross-functionally with the internal research team and will be responsible for conducting the required in vivo research experiments. The ideal candidate will have multi-tasking ability and a desire to thrive in a fast-paced environment.

Some specific duties and tasks include, but are not limited to, the following:

  • Design and conduct SPECT/PET/CT imaging protocols for rodent models, perform image reconstruction and analysis.
  • Maintain and calibrate microSPECT/PET/CT equipment (e.g., periodic QA/QC protocols, troubleshooting)
  • Execute other animal experiments including but not limited to ex vivo tissue harvest, biodistribution and therapy studies.
  • Perform animal handling, injections, surgery, post-operative care, monitoring, blood sampling and tissue collection.
  • Maintain clear and accurate lab records and laboratory compliances (e.g., monitoring sheets, health reports, data spreadsheets, radiation safety)
  • Write, review, and execute SOPs and animal protocols.
  • Produce high quality and well documented data with strong attention to detail.
  • Contribute to internal project teams through the setting and achievement of scientific goals, communication of results, and solving multifaceted scientific challenges.
  • Perform other research tasks, as required.

Qualifications:

  • PhD in relevant discipline with 2-5 years of industrial experience with laboratory animals or an equivalent combination of education and experience.
  • 1-3 years knowledge and experience working with SPECT/PET/CT methods and instrumentations, image analysis and handling of radioactive substances.
  • Experience with rodent handling and in vivo experiments including data analysis.
  • Experience with radiopharmaceuticals development is preferred but not mandatory.
  • Strong knowledge in laboratory animal standards and CCAC guidelines is an asset.
  • Ability to work independently in a laboratory environment.
  • Ability to communicate the results in meetings.
  • Observational, organizational, data management and documentation skills.
  • A strong team-player with excellent interpersonal skills who is willing to make a real impact and accelerate the development of innovative target therapies in a fast-paced environment.
  • Proven analytical, critical thinking, problem solving, decision-making and organizational skills.

What’s in it for you:

  • Full extended health and dental benefits
  • Competitive Salary, Bonus, and Equity
  • Commuter Reimbursement
  • Group Registered Retirement Savings Plan with employer matching.
  • 20 vacation days
  • 14 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

Location: Vancouver, BC

To apply, use the form below.

Don’t see anything that matches your experience? Email us at careers@a9oncology.com

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